What is 5-ALA?

5-ALA (5-Aminolevulinic Acid) is a naturally occurring amino acid that plays a key role in your skin’s energy production.

Found in small amounts in everyday foods like spinach, tomatoes, and potatoes, 5-ALA is already part of your body’s natural biology.

By supporting the mitochondria — the “powerhouses” of your skin cells — 5-ALA helps boost collagen, hydrate deeply, and visibly reduce fine lines.

How does it work?

When combined with iron, 5-ALA phosphate fuels the cellular energy cycle by supporting the production of Heme, a key molecule in the mitochondrial electron transport chain.

In simpler terms: 5-ALA helps your skin cells convert nutrients into energy (ATP) — the very fuel that powers healthy skin.

This cellular energy is critical for:

  • Collagen and elastin production
  • Skin cell renewal
  • Deep hydration and moisture retention

See 5-ALA in Action

Explore the benefits of 5-ALA

Clinically Proven – Studies on 5-ALA

In a clinical study, 45 women tested 5-ALA-based skincare over an 8-week period. The results?

  • Significant increase in skin hydration after just 4 weeks

  • Visible reduction in fine lines and wrinkles

These findings confirm the hydrating and smoothing effects of 5-ALA are scientifically proven.

Source: Naraoka et al., Health Journal, 2020

5-ALA Skincare FAQ - Your Questions Answered

What is 5-ALA in skincare?

5-ALA (5-Aminolevulinic Acid) is a naturally occurring amino acid that supports cellular energy production in the skin.

Found in small amounts in foods like spinach and tomatoes, 5-ALA helps energize skin cells, making it a powerful ingredient for improving hydration, firmness, and glow.
How does 5-ALA work on the skin?

In skincare, 5-ALA stimulates the mitochondria, known as the "powerhouses" of skin cells.

This boosts the production of ATP (cellular energy), which helps the skin to generate collagen and elastin, retain moisture, and regenerate more effectively — resulting in smoother, more radiant skin.
Is 5-ALA safe for daily use?

ALA are dermatologically tested and suitable for daily use as part of your skincare routine.
When can I expect to see visible results with 5-ALA skincare?

In a clinical study, participants saw a measurable increase in skin hydration after just 4 weeks, along with a visible reduction in wrinkle depth and fine lines. Results may vary depending on skin type and consistency of use.
Is 5-ALA a natural skincare ingredient?

Yes. 5-ALA occurs naturally in the human body and in small amounts in foods like spinach, tomatoes, and potatoes.

In skincare, it is biotechnologically derived for purity, safety, and effectiveness.
Can I combine 5-ALA with other skincare ingredients?

Absolutely. 5-ALA pairs well with hydrating agents like hyaluronic acid, barrier-supporting ingredients like ceramides, and even brightening actives like Vitamin C. It’s a versatile and gentle base for many routines.
Is there scientific research supporting the effectiveness of 5-ALA in skincare?

Yes. A Japanese double-blind clinical study confirmed that 5-ALA significantly increased skin moisture and reduced the depth of wrinkles after just four weeks of regular use.

Source: Naraoka et al., Health Journal, 2020.
Is 5-ALA vegan and cruelty-free?

Yes. The 5-ALA used in KIYOMI SKIN products is vegan, biotechnologically produced, and our skincare is never tested on animals.
What are the skincare benefits of 5-ALA?

5-ALA is ideal for anyone looking to:

  • Deep hydration and moisture retention
  • Visible reduction in fine lines and wrinkles
  • Improved skin elasticity and firmness
  • Supports cell renewal and repair
  • Long-term radiance and skin resilience
Is 5-ALA safe for all skin types?

Yes. 5-ALA is dermatologically tested and considered safe for all skin types, including sensitive skin.

At KIYOMI SKIN, we formulate with clean, biocompatible ingredients to ensure high tolerance and daily use.
Who should use 5-ALA skincare products?

5-ALA is perfect for those looking to:

  • Improve skin hydration and glow
  • Prevent or reduce signs of aging
  • Boost collagen production naturally
  • Strengthen and support skin from the inside out
  • Build a science-based, minimalist skincare routine